Upuść kolumny nieokreślone w pandy
df = df.loc[:, ~df.columns.str.contains('^Unnamed')]
In [162]: df
Out[162]:
colA ColB colC colD colE colF colG
0 44 45 26 26 40 26 46
1 47 16 38 47 48 22 37
2 19 28 36 18 40 18 46
3 50 14 12 33 12 44 23
4 39 47 16 42 33 48 38
Homely Hornet