Pandy wybierz wszystkie kolumny oprócz jednej
df.loc[:, df.columns != 'b']
a c d
0 0.561196 0.013768 0.772827
1 0.882641 0.615396 0.075381
2 0.368824 0.651378 0.397203
3 0.788730 0.568099 0.869127
Happy Hawk